In 1953, Sothern moved into television as the star of her own sitcom Private Secretary. The series aired for five seasons on CBS and earned Sothern three Primetime Emmy Award nominations. In 1958, she starred in another sitcom for CBS, The Ann Sothern Show which aired for three seasons. From 1965 to 1966, Sothern provided the voice of Gladys Crabtree in the sitcom My Mother the Car. She continued her career throughout the late 1960s with stage and film appearances and guest starring roles on television. Due to health issues, she worked sporadically during the 1970s and 1980s.